Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans.Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6.In vitro studies have suggested these mutations affect several signaling pathways, but in vivo studies have largely compared wild-t
Understanding the corneal mechanical properties has great importance in the study of corneal pathologies and the prediction of refractive surgery outcomes.Non-Contact Tonometry (NCT) is a non-invasive diagnostic tool intended to characterize the corneal tissue response in vivo by applying a defined air-pulse.The biomarkers inferred from this test c
The novel "Laurus" by E.G.Vodolazkin, written in the form of life, takes the reader to Medieval Russia of the XV century.The teleological plot, characteristic of RAW ORG PROTEIN medieval or synodic texts: Sin-Prayer-Absolution of sins-Edification in the novel is overgrown with numerous episodes and plot Tortilla Servers lines, but retains its sacra